A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion
نویسندگان
چکیده
منابع مشابه
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans.
Although excess visceral fat is associated with noninfectious inflammation, it is not clear whether visceral fat is simply associated with or actually causes metabolic disease in humans. To evaluate the hypothesis that visceral fat promotes systemic inflammation by secreting inflammatory adipokines into the portal circulation that drains visceral fat, we determined adipokine arteriovenous conce...
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CONTEXT Adipocytes are known to release a variety of factors that may contribute to the proinflammatory state characteristic for obesity. This secretory function is considered to provide the basis for obesity-related complications such as type 2 diabetes and atherosclerosis. OBJECTIVE To get a better insight into possible underlying mechanisms, we investigated the effect of adipocyte size on ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2017
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2017.09.007